{"symbol":"HDAC4","synonyms":["HDAC-4","HA6116","BDMR","HDAC-A","HD4","HDACA","AHO3"],"name":"histone deacetylase 4","description":"Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":9759,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9759","proteins":[{"symbol":"HDAC4_HUMAN","href":"/api/1.0/protein/HDAC4_HUMAN"}],"hgncRootFamilies":[]}