{"symbol":"HDAC6","synonyms":["PPP1R90","JM21","CPBHM"],"name":"histone deacetylase 6","description":"Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":10013,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10013","proteins":[{"symbol":"HDAC6_HUMAN","href":"/api/1.0/protein/HDAC6_HUMAN"}],"hgncRootFamilies":[{"name":"Protein phosphatase 1 regulatory subunits (PPP1R)","href":"/api/1.0/gene_family/Protein+phosphatase+1+regulatory+subunits+%28PPP1R%29"}]}