{"symbol":"HERC2","synonyms":["JDF2","P528","MRT38","D15F37S1"],"name":"HECT and RLD domain containing E3 ubiquitin protein ligase 2","description":"This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012]","ncbiEntrezGeneId":8924,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8924","proteins":[{"symbol":"HERC2_HUMAN","href":"/api/1.0/protein/HERC2_HUMAN"}],"hgncRootFamilies":[]}