{"symbol":"HERC4","synonyms":[],"name":"HECT and RLD domain containing E3 ubiquitin protein ligase 4","description":"HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]","ncbiEntrezGeneId":26091,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/26091","proteins":[{"symbol":"HERC4_HUMAN","href":"/api/1.0/protein/HERC4_HUMAN"}],"hgncRootFamilies":[]}