{"symbol":"HERC5","synonyms":["CEBP1","CEB1"],"name":"HECT and RLD domain containing E3 ubiquitin protein ligase 5","description":"This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The protein also acts as a modulator of the antiviral immune response. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Aug 2021]","ncbiEntrezGeneId":51191,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/51191","proteins":[{"symbol":"HERC5_HUMAN","href":"/api/1.0/protein/HERC5_HUMAN"}],"hgncRootFamilies":[]}