{"symbol":"HIF3A","synonyms":["HIF-3A","MOP7","PASD7","HIF3-alpha-1","IPAS","BHLHE17"],"name":"hypoxia inducible factor 3, alpha subunit","description":"The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]","ncbiEntrezGeneId":64344,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/64344","proteins":[{"symbol":"HIF3A_HUMAN","href":"/api/1.0/protein/HIF3A_HUMAN"}],"hgncRootFamilies":[{"name":"Basic helix-loop-helix proteins (BHLH)","href":"/api/1.0/gene_family/Basic+helix-loop-helix+proteins+%28BHLH%29"}]}