{"symbol":"HIST1H2AD","synonyms":["H2A.3","H2A/G","H2AFG"],"name":"histone cluster 1, H2ad","description":"Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]","ncbiEntrezGeneId":3013,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3013","proteins":[{"symbol":"H2A1D_HUMAN","href":"/api/1.0/protein/H2A1D_HUMAN"}],"hgncRootFamilies":[{"name":"Histones","href":"/api/1.0/gene_family/Histones"}]}