{"symbol":"HIST1H3B","synonyms":["H3/L","H3FL"],"name":"histone cluster 1, H3b","description":"Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]","ncbiEntrezGeneId":8358,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8358","proteins":[],"hgncRootFamilies":[{"name":"Histones","href":"/api/1.0/gene_family/Histones"}]}