{"symbol":"HIST2H3A","synonyms":["H3/N","H3/O"],"name":"histone cluster 2, H3a","description":"Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Aug 2015]","ncbiEntrezGeneId":333932,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/333932","proteins":[{"symbol":"H32_HUMAN","href":"/api/1.0/protein/H32_HUMAN"}],"hgncRootFamilies":[{"name":"Histones","href":"/api/1.0/gene_family/Histones"}]}