{"symbol":"HIST3H3","synonyms":["H3.4","H3FT","H3/G","H3T"],"name":"histone cluster 3, H3","description":"Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]","ncbiEntrezGeneId":8290,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8290","proteins":[{"symbol":"H31T_HUMAN","href":"/api/1.0/protein/H31T_HUMAN"}],"hgncRootFamilies":[{"name":"Histones","href":"/api/1.0/gene_family/Histones"}]}