{"symbol":"HLA-DOA","synonyms":["HLA-DNA","HLA-DZA","HLADZ"],"name":"major histocompatibility complex, class II, DO alpha","description":"HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":3111,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3111","proteins":[{"symbol":"DOA_HUMAN","href":"/api/1.0/protein/DOA_HUMAN"}],"hgncRootFamilies":[{"name":"Histocompatibility complex (HLA)","href":"/api/1.0/gene_family/Histocompatibility+complex+%28HLA%29"},{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"}]}