{"symbol":"HLA-DOB","synonyms":["DOB","HLA_DOB"],"name":"major histocompatibility complex, class II, DO beta","description":"HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":3112,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3112","proteins":[{"symbol":"DOB_HUMAN","href":"/api/1.0/protein/DOB_HUMAN"}],"hgncRootFamilies":[{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"},{"name":"Histocompatibility complex (HLA)","href":"/api/1.0/gene_family/Histocompatibility+complex+%28HLA%29"}]}