{"symbol":"HLA-DPB1","synonyms":["DPB1","HLA-DP","HLA-DP1B","HLA-DPB"],"name":"major histocompatibility complex, class II, DP beta 1","description":"HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":3115,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3115","proteins":[{"symbol":"DPB1_HUMAN","href":"/api/1.0/protein/DPB1_HUMAN"}],"hgncRootFamilies":[{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"},{"name":"Histocompatibility complex (HLA)","href":"/api/1.0/gene_family/Histocompatibility+complex+%28HLA%29"}]}