{"symbol":"HLA-E","synonyms":["EA2.1","HLA-6.2","QA1","MHC","EA1.2"],"name":"major histocompatibility complex, class I, E","description":"HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":3133,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3133","proteins":[{"symbol":"HLAE_HUMAN","href":"/api/1.0/protein/HLAE_HUMAN"}],"hgncRootFamilies":[{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"},{"name":"Histocompatibility complex (HLA)","href":"/api/1.0/gene_family/Histocompatibility+complex+%28HLA%29"}]}