{"symbol":"HLA-G","synonyms":["MHC-G"],"name":"major histocompatibility complex, class I, G","description":"HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":3135,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3135","proteins":[{"symbol":"HLAG_HUMAN","href":"/api/1.0/protein/HLAG_HUMAN"}],"hgncRootFamilies":[{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"},{"name":"Histocompatibility complex (HLA)","href":"/api/1.0/gene_family/Histocompatibility+complex+%28HLA%29"}]}