{"symbol":"HLF","synonyms":[],"name":"hepatic leukemia factor","description":"This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":3131,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3131","proteins":[{"symbol":"HLF_HUMAN","href":"/api/1.0/protein/HLF_HUMAN"}],"hgncRootFamilies":[]}