{"symbol":"HMGA2","synonyms":["BABL","HMGI-C","LIPO","HMGIC","STQTL9"],"name":"high mobility group AT-hook 2","description":"This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":8091,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8091","proteins":[{"symbol":"HMGA2_HUMAN","href":"/api/1.0/protein/HMGA2_HUMAN"}],"hgncRootFamilies":[{"name":"High mobility group (HMG)","href":"/api/1.0/gene_family/High+mobility+group+%28HMG%29"}]}