{"symbol":"HMOX2","synonyms":["HO-2"],"name":"heme oxygenase 2","description":"Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]","ncbiEntrezGeneId":3163,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3163","proteins":[{"symbol":"HMOX2_HUMAN","href":"/api/1.0/protein/HMOX2_HUMAN"}],"hgncRootFamilies":[]}