{"symbol":"HNF1B","synonyms":["VHNF1","LFB3","TCF2","HNF2","HPC11","TCF-2","FJHN","HNF-1-BETA","HNF-1B","LF-B3","HNF1BETA","MODY5"],"name":"HNF1 homeobox B","description":"This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]","ncbiEntrezGeneId":6928,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6928","proteins":[{"symbol":"HNF1B_HUMAN","href":"/api/1.0/protein/HNF1B_HUMAN"}],"hgncRootFamilies":[{"name":"Homeoboxes","href":"/api/1.0/gene_family/Homeoboxes"}]}