{"symbol":"HOMER3","synonyms":["HOMER-3","VESL3"],"name":"homer scaffolding protein 3","description":"This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]","ncbiEntrezGeneId":9454,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9454","proteins":[{"symbol":"HOME3_HUMAN","href":"/api/1.0/protein/HOME3_HUMAN"}],"hgncRootFamilies":[{"name":"Homer scaffolding proteins  (HOMER)","href":"/api/1.0/gene_family/Homer+scaffolding+proteins++%28HOMER%29"}]}