{"symbol":"HOXB5","synonyms":["HHO.C10","HOX2.1","HOX2A","HU-1"],"name":"homeobox B5","description":"This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":3215,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3215","proteins":[{"symbol":"HXB5_HUMAN","href":"/api/1.0/protein/HXB5_HUMAN"}],"hgncRootFamilies":[{"name":"Homeoboxes","href":"/api/1.0/gene_family/Homeoboxes"}]}