{"symbol":"HSH2D","synonyms":["ALX","HSH2"],"name":"hematopoietic SH2 domain containing","description":"T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).[supplied by OMIM, Mar 2008]","ncbiEntrezGeneId":84941,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/84941","proteins":[{"symbol":"HSH2D_HUMAN","href":"/api/1.0/protein/HSH2D_HUMAN"}],"hgncRootFamilies":[{"name":"SH2 domain containing","href":"/api/1.0/gene_family/SH2+domain+containing"}]}