{"symbol":"HSPH1","synonyms":["NY-CO-25","HSP105A","HSP105","HSP105B"],"name":"heat shock 105kDa/110kDa protein 1","description":"This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. [provided by RefSeq, Mar 2017]","ncbiEntrezGeneId":10808,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10808","proteins":[{"symbol":"HS105_HUMAN","href":"/api/1.0/protein/HS105_HUMAN"}],"hgncRootFamilies":[{"name":"Heat shock proteins","href":"/api/1.0/gene_family/Heat+shock+proteins"}]}