{"symbol":"HTR2A","synonyms":["5-HT2A","HTR2"],"name":"5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled","description":"This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]","ncbiEntrezGeneId":3356,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3356","proteins":[{"symbol":"5HT2A_HUMAN","href":"/api/1.0/protein/5HT2A_HUMAN"}],"hgncRootFamilies":[{"name":"5-hydroxytryptamine (serotonin) receptors (HTR)","href":"/api/1.0/gene_family/5-hydroxytryptamine+%28serotonin%29+receptors+%28HTR%29"},{"name":"G protein-coupled receptors","href":"/api/1.0/gene_family/G+protein-coupled+receptors"}]}