{"symbol":"HTR2B","synonyms":["5-HT-2B","5-HT2B","5-HT(2B)"],"name":"5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled","description":"This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]","ncbiEntrezGeneId":3357,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3357","proteins":[{"symbol":"5HT2B_HUMAN","href":"/api/1.0/protein/5HT2B_HUMAN"}],"hgncRootFamilies":[{"name":"5-hydroxytryptamine (serotonin) receptors (HTR)","href":"/api/1.0/gene_family/5-hydroxytryptamine+%28serotonin%29+receptors+%28HTR%29"},{"name":"G protein-coupled receptors","href":"/api/1.0/gene_family/G+protein-coupled+receptors"}]}