{"symbol":"HTRA1","synonyms":["ARMD7","ORF480","PRSS11","CADASIL2","L56","CARASIL","HTRA"],"name":"HtrA serine peptidase 1","description":"This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":5654,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5654","proteins":[{"symbol":"HTRA1_HUMAN","href":"/api/1.0/protein/HTRA1_HUMAN"}],"hgncRootFamilies":[{"name":"Proteases, serine (PRSS)","href":"/api/1.0/gene_family/Proteases%2C+serine+%28PRSS%29"}]}