{"symbol":"IARS","synonyms":["ILERS","IRS","ILRS","PRO0785","GRIDHH","IARS1"],"name":"isoleucyl-tRNA synthetase","description":"Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2012]","ncbiEntrezGeneId":3376,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3376","proteins":[{"symbol":"SYIC_HUMAN","href":"/api/1.0/protein/SYIC_HUMAN"}],"hgncRootFamilies":[{"name":"Aminoacyl tRNA synthetases","href":"/api/1.0/gene_family/Aminoacyl+tRNA+synthetases"}]}