{"symbol":"IBTK","synonyms":["BTBD26","BTKI"],"name":"inhibitor of Bruton agammaglobulinemia tyrosine kinase","description":"Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK\u0027s kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]","ncbiEntrezGeneId":25998,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/25998","proteins":[{"symbol":"IBTK_HUMAN","href":"/api/1.0/protein/IBTK_HUMAN"}],"hgncRootFamilies":[{"name":"Ankyrin repeat domain containing (ANKRD)","href":"/api/1.0/gene_family/Ankyrin+repeat+domain+containing+%28ANKRD%29"},{"name":"BTB (POZ) domain containing (BTBD)","href":"/api/1.0/gene_family/BTB+%28POZ%29+domain+containing+%28BTBD%29"}]}