{"symbol":"ICAM3","synonyms":["CD50","ICAM-R","CDW50"],"name":"intercellular adhesion molecule 3","description":"The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]","ncbiEntrezGeneId":3385,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3385","proteins":[{"symbol":"ICAM3_HUMAN","href":"/api/1.0/protein/ICAM3_HUMAN"}],"hgncRootFamilies":[{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"},{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"}]}