{"symbol":"ICAM4","synonyms":["LW","CD242"],"name":"intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)","description":"This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100\u003dLW(A) and Arg-100\u003dLW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":3386,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3386","proteins":[{"symbol":"ICAM4_HUMAN","href":"/api/1.0/protein/ICAM4_HUMAN"}],"hgncRootFamilies":[{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"},{"name":"Blood group antigens","href":"/api/1.0/gene_family/Blood+group+antigens"},{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"}]}