{"symbol":"IDH3A","synonyms":[],"name":"isocitrate dehydrogenase 3 (NAD+) alpha","description":"Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":3419,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3419","proteins":[{"symbol":"IDH3A_HUMAN","href":"/api/1.0/protein/IDH3A_HUMAN"}],"hgncRootFamilies":[]}