{"symbol":"IDH3B","synonyms":["RP46","H-IDHB"],"name":"isocitrate dehydrogenase 3 (NAD+) beta","description":"Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2016]","ncbiEntrezGeneId":3420,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3420","proteins":[{"symbol":"IDH3B_HUMAN","href":"/api/1.0/protein/IDH3B_HUMAN"}],"hgncRootFamilies":[]}