{"symbol":"IDI2","synonyms":["IPPI2"],"name":"isopentenyl-diphosphate delta isomerase 2","description":"The protein encoded by this gene catalyzes the conversion of isopentenyl diphosphate to dimethylallyl diphosphate, which is a precursor for the synthesis of cholesterol and other isoprenoids. This gene, which is a product of an ancestral gene duplication event, encodes a protein that may be involved in the aggregation of alpha-synuclein in the cerebral cortex of patients with Lewy body disease. In addition, segmental copy number gains in this locus have been associated with sporadic amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2016]","ncbiEntrezGeneId":91734,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/91734","proteins":[{"symbol":"IDI2_HUMAN","href":"/api/1.0/protein/IDI2_HUMAN"}],"hgncRootFamilies":[]}