{"symbol":"IFI16","synonyms":["IFNGIP1","PYHIN2"],"name":"interferon, gamma-inducible protein 16","description":"This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]","ncbiEntrezGeneId":3428,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3428","proteins":[{"symbol":"IF16_HUMAN","href":"/api/1.0/protein/IF16_HUMAN"}],"hgncRootFamilies":[]}