{"symbol":"IGF1R","synonyms":["IGFR","JTK13","CD221","IGFIR"],"name":"insulin-like growth factor 1 receptor","description":"This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]","ncbiEntrezGeneId":3480,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3480","proteins":[{"symbol":"IGF1R_HUMAN","href":"/api/1.0/protein/IGF1R_HUMAN"}],"hgncRootFamilies":[{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"},{"name":"Receptor kinases","href":"/api/1.0/gene_family/Receptor+kinases"},{"name":"Fibronectin type III domain containing","href":"/api/1.0/gene_family/Fibronectin+type+III+domain+containing"}]}