{"symbol":"IGFALS","synonyms":["ALS","ACLSD"],"name":"insulin-like growth factor binding protein, acid labile subunit","description":"The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]","ncbiEntrezGeneId":3483,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3483","proteins":[{"symbol":"ALS_HUMAN","href":"/api/1.0/protein/ALS_HUMAN"}],"hgncRootFamilies":[]}