{"symbol":"IKZF1","synonyms":["LYF-1","HS.54452","PPP1R92","IKAROS","LYF1","ZNFN1A1","PRO0758","CVID13"],"name":"IKAROS family zinc finger 1 (Ikaros)","description":"This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]","ncbiEntrezGeneId":10320,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10320","proteins":[{"symbol":"IKZF1_HUMAN","href":"/api/1.0/protein/IKZF1_HUMAN"}],"hgncRootFamilies":[{"name":"Protein phosphatase 1 regulatory subunits (PPP1R)","href":"/api/1.0/gene_family/Protein+phosphatase+1+regulatory+subunits+%28PPP1R%29"},{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}