{"symbol":"IKZF3","synonyms":["AIO","AIOLOS","ZNFN1A3"],"name":"IKAROS family zinc finger 3 (Aiolos)","description":"This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]","ncbiEntrezGeneId":22806,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/22806","proteins":[{"symbol":"IKZF3_HUMAN","href":"/api/1.0/protein/IKZF3_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}