{"symbol":"IL12RB1","synonyms":["IL-12R-BETA1","IMD30","CD212","IL12RB"],"name":"interleukin 12 receptor, beta 1","description":"The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]","ncbiEntrezGeneId":3594,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3594","proteins":[{"symbol":"I12R1_HUMAN","href":"/api/1.0/protein/I12R1_HUMAN"}],"hgncRootFamilies":[{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"},{"name":"Interleukin receptors","href":"/api/1.0/gene_family/Interleukin+receptors"},{"name":"Fibronectin type III domain containing","href":"/api/1.0/gene_family/Fibronectin+type+III+domain+containing"}]}