{"symbol":"IL12RB2","synonyms":[],"name":"interleukin 12 receptor, beta 2","description":"The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn\u0027s disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]","ncbiEntrezGeneId":3595,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3595","proteins":[{"symbol":"I12R2_HUMAN","href":"/api/1.0/protein/I12R2_HUMAN"}],"hgncRootFamilies":[{"name":"Interleukin receptors","href":"/api/1.0/gene_family/Interleukin+receptors"},{"name":"Fibronectin type III domain containing","href":"/api/1.0/gene_family/Fibronectin+type+III+domain+containing"}]}