{"symbol":"IL17RA","synonyms":["CD217","IMD51","IL-17RA","HIL-17R","CANDF5","CDW217","IL17R"],"name":"interleukin 17 receptor A","description":"Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]","ncbiEntrezGeneId":23765,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/23765","proteins":[{"symbol":"I17RA_HUMAN","href":"/api/1.0/protein/I17RA_HUMAN"}],"hgncRootFamilies":[{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"},{"name":"Interleukin receptors","href":"/api/1.0/gene_family/Interleukin+receptors"}]}