{"symbol":"IL18R1","synonyms":["IL18RA","CD218A","CDW218A","IL1RRP","IL-1RRP"],"name":"interleukin 18 receptor 1","description":"The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]","ncbiEntrezGeneId":8809,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8809","proteins":[{"symbol":"IL18R_HUMAN","href":"/api/1.0/protein/IL18R_HUMAN"}],"hgncRootFamilies":[{"name":"Interleukin receptors","href":"/api/1.0/gene_family/Interleukin+receptors"},{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"},{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"}]}