{"symbol":"IL1A","synonyms":["IL1","IL-1A","IL1F1","IL1-ALPHA"],"name":"interleukin 1, alpha","description":"The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer\u0027s disease. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":3552,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3552","proteins":[{"symbol":"IL1A_HUMAN","href":"/api/1.0/protein/IL1A_HUMAN"}],"hgncRootFamilies":[{"name":"Endogenous ligands","href":"/api/1.0/gene_family/Endogenous+ligands"},{"name":"Interleukins (IL)","href":"/api/1.0/gene_family/Interleukins+%28IL%29"}]}