{"symbol":"IL1R2","synonyms":["CD121B","IL-1R-2","CDW121B","IL-1RT-2","IL1R2C","IL1RB","IL-1RT2"],"name":"interleukin 1 receptor, type II","description":"The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]","ncbiEntrezGeneId":7850,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7850","proteins":[{"symbol":"IL1R2_HUMAN","href":"/api/1.0/protein/IL1R2_HUMAN"}],"hgncRootFamilies":[{"name":"Interleukin receptors","href":"/api/1.0/gene_family/Interleukin+receptors"},{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"},{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"}]}