{"symbol":"IL1RAPL1","synonyms":["MRX10","IL-1-RAPL-1","IL-1RAPL-1","IL1RAPL-1","IL1R8","OPHN4","IL1RAPL","MRX34","TIGIRR-2","MRX21"],"name":"interleukin 1 receptor accessory protein-like 1","description":"The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. This protein has an N-terminal signal peptide, three extracellular immunoglobulin Ig-like domains, a transmembrane domain, an intracellular Toll/IL-1R domain, and a long C-terminal tail which interacts with multiple signalling molecules. This gene is located at a region on chromosome X that is associated with a non-syndromic form of X-linked intellectual disability. Deletions and mutations in this gene were found in patients with intellectual disability. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities, and plays a role in synapse formation and stabilization. [provided by RefSeq, Jul 2017]","ncbiEntrezGeneId":11141,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/11141","proteins":[{"symbol":"IRPL1_HUMAN","href":"/api/1.0/protein/IRPL1_HUMAN"}],"hgncRootFamilies":[{"name":"X-linked mental retardation","href":"/api/1.0/gene_family/X-linked+mental+retardation"},{"name":"Interleukin receptors","href":"/api/1.0/gene_family/Interleukin+receptors"},{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"}]}