{"symbol":"IL1RN","synonyms":["IL1F3","IL-1RA3","IRAP","IL-1RA","ICIL-1RA","IL-1RN","DIRA","MVCD4"],"name":"interleukin 1 receptor antagonist","description":"The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses, particularly in the acute phase of infection and inflammation. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020]","ncbiEntrezGeneId":3557,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3557","proteins":[{"symbol":"IL1RA_HUMAN","href":"/api/1.0/protein/IL1RA_HUMAN"}],"hgncRootFamilies":[{"name":"Interleukin receptors","href":"/api/1.0/gene_family/Interleukin+receptors"},{"name":"Interleukins (IL)","href":"/api/1.0/gene_family/Interleukins+%28IL%29"},{"name":"Endogenous ligands","href":"/api/1.0/gene_family/Endogenous+ligands"}]}