{"symbol":"IL21","synonyms":["CVID11","ZA11"],"name":"interleukin 21","description":"This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]","ncbiEntrezGeneId":59067,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/59067","proteins":[{"symbol":"IL21_HUMAN","href":"/api/1.0/protein/IL21_HUMAN"}],"hgncRootFamilies":[{"name":"Interleukins (IL)","href":"/api/1.0/gene_family/Interleukins+%28IL%29"}]}