{"symbol":"IL27","synonyms":["IL27A","IL30","IL27P28","IL-27","IL-27A"],"name":"interleukin 27","description":"The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":246778,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/246778","proteins":[{"symbol":"IL27A_HUMAN","href":"/api/1.0/protein/IL27A_HUMAN"}],"hgncRootFamilies":[{"name":"Interleukins (IL)","href":"/api/1.0/gene_family/Interleukins+%28IL%29"}]}