{"symbol":"IL36G","synonyms":["IL1RP2","IL-1H1","IL1H1","IL-1F9","IL1E","IL-1RP2","IL1F9"],"name":"interleukin 36, gamma","description":"The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, May 2019]","ncbiEntrezGeneId":56300,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/56300","proteins":[{"symbol":"IL36G_HUMAN","href":"/api/1.0/protein/IL36G_HUMAN"}],"hgncRootFamilies":[{"name":"Interleukins (IL)","href":"/api/1.0/gene_family/Interleukins+%28IL%29"}]}