{"symbol":"IL37","synonyms":["IL-1RP1","IL1F7","IL1H4","FIL1(ZETA)","IL1RP1","IL-1F7","IL-1H","IL-1H4","FIL1Z","IL-37"],"name":"interleukin 37","description":"The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":27178,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/27178","proteins":[{"symbol":"IL37_HUMAN","href":"/api/1.0/protein/IL37_HUMAN"}],"hgncRootFamilies":[{"name":"Interleukins (IL)","href":"/api/1.0/gene_family/Interleukins+%28IL%29"}]}